- BioPerine® is a patented standardized extract obtained from black pepper, containing not less than 95% piperine
- A clinically proven bioavailability enhancer for nutrients1
Bioavailability
- Bioavailability is “the quantity of a substance, either nutrient, drug, or toxicant, that effectively reaches the target cells where it modifies, for good or bad, their metabolism and consequently their fate”.1
1 Basu, T.K.: The influence of drugs with particular reference to aspirin on bioavailability of Vitamin C; in Counsell, Hornig, Vitamin C, pp.273-281 (Applied Science Publishers, Barking 1981)
Characteristic Features
- Gram positive, Indole negative, rod shaped bacteria with terminal spores
- Produces L(+) Lactic Acid only
- Naturally microencapsulated for stability
- Proliferates within the GI tract
- Extremely fastidious organisms
- Grow optimally at 30°C to 37°C & optimum pH in the range 5.5 to 6.2
- Microaerophilic
- The acidic environment created by production of L(+) Lactic Acid & other antimicrobial compounds prevents the growth of disease causing microbes like Clostridia, which are responsible for production of undesirable gases
- Long & slender cells (0.3 to 0.8 microns)
- Colonies are usually 2.5 mm in diameter, convex, smooth, glistening and do not produce any pigment
A natural bioavailability enhancer for nutrients
- Herbal extracts
- e.g. curcumin, Boswellin®, ashwagandha, Gingko biloba, capsaicin
- Water-soluble vitamins
- e.g. vitamin B1, vitamin B2, niacinamide, vitamin B6, vitamin B12, folic acid, vitamin C
- Fat-soluble vitamins
- e.g. vitamin A, vitamin D, vitamin E, vitamin K
- Antioxidants
- e.g. vitamin A, vitamin C, vitamin E, alpha-carotene, transbeta-carotene, beta-cryptoxanthin, lycopene, lutein/zeaxanthin, pine bark bioflavanoids complex, germanium, selenium, zinc
- Amino Acids
- e.g. lysine, isoleucine, leucine, threonoine, valine, tryptophan, phenylalanine, methionine
- Minerals
- e.g calcium, iron, zinc, vanadium, selenium, chromium, iodine, potassium, manganese, copper, magnesium
Possible mechanisms for increased nutrient bioavailability using BioPerine®
- Non specific mechanisms promoting rapid absorption of nutrients
- Increases blood supply to the GI tract
- Water-soluble vitamins
- Increases emulsifying content of the gut
- Fat-soluble vitamins
- Increases active nutrient transport
Average daily consumption of piperine with black pepper vs. daily requirements for BioPerine®
*Estimated daily consumption of piperine with black pepper
Data based on doctoral thesis by Shore Scott Kindell, Drexel University, 1984
** Estimated daily consumption of BioPerine®
“Once the window of opportunity for piperine-nutrient interaction has been missed nutrient absorption is not enhanced”
-Nutrition Science News, March 1996
BioPerine® increased the absorption of co-administered beta-carotene in human volunteers
*Estimated daily consumption of piperine with black pepper
Data based on doctoral thesis by Shore Scott Kindell, Drexel University, 1984
** Estimated daily consumption of BioPerine®
Effect of BioPerine® on serum selenium levels during a 6 week supplementation trial in human volunteers
Efficacy of BioPerine® (5 mg) on the bioavailability of Vitamin B6 absorption in human volunteers
Effect of BioPerine® on serum CoQ10 levels during a 21 day supplementation trial
Effect of BioPerine® on Serum Concentrations of Curcumin in Human Volunteers
Multivitamin Bioavailability (+/- Piperine)
- Piperine supplementation significantly increased the bioavailability of vitamin C and vitamin E from the standard multivitamin formulation
- The bioavailability of vitamin B6, B12, Betacarotene, or calcium was improved with piperine supplementation
